Pharmacokinetics. General examination and investigation of persons without complaint and reported diagnosis
Conditions
Interventions
Intervention 1: Control group: administration placebo one capsule daily for three days before midazolam (10 mg oral single dose). Intervention 2: Piperine group: administration piperine (15 mg) one ca
Treatment - Drugs
Control group: administration placebo one capsule daily for three days before midazolam (10 mg oral single dose).
Piperine group: administration piperine (15 mg) one capsule daily for three days before midazolam (10 mg oral single dose).
Sponsors
Babol University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 35 Years
Inclusion criteria
Inclusion criteria: After providing adequate information to the subjects, eligible healthy volunteer will be enrolled in the study. Inclusion criteria: be healthy; normal diet; not receiving microsomal enzyme inhibitor or inducer agents for at least 7 days before the study; not using black pepper for at least 7 days before the study. Exclusion criteria: age below 18 and above 35; smoking; pregnancy; metabolic disorders; high pepper diet, receiving enzyme inhibitors or inducers.
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Midazolam Placema Concentration. Timepoint: Only once in fourth day of the study 0.5, 2.5 and 5 h after taking midazolam. Method of measurement: Using HPLC method (reverse phase; Water 25, Methanol 75, flow rate 0.8 ml/min, maximum wave lengh 242 nm). | — |
Secondary
| Measure | Time frame |
|---|---|
| -. Timepoint: -. Method of measurement: -. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactDr. Ali Akbar Moghadamnia
Babol University of Medical Sciences
Outcome results
None listed