Rhumatoid arthritis. Seropositive rheumatoid arthritis
Conditions
Interventions
A tablet supplementation antioxidant compounds, including supplementation with a combination of selenium, zinc, vitamin A, E and C to form oral supplement "Celine Plus" is the order of 50 mg, 8 mg, 40
Treatment - Drugs
Sponsors
Pharmaceutical research center, Tabriz University of Medical Sciences
Eligibility
Sex/Gender
Female
Age
30 Years to 60 Years
Inclusion criteria
Inclusion criteria: People with diagnosis of Rheumatoid arthritis disease according to American College of Rheumatology criteria (ACR) is confirmed. The doctor diagnosed according to criteria ACR (at least 4 criteria for six weeks : 1 - morning stiffness in the joint for at least an hour or more 2 - articular arthritis in three areas or more4: hand joint arthritis 5- symmetrical arthritis 5 - rheumatoid nodules 6 - positive rheumatoid factor 7 - typical radiographic changes in the wrist and hand) in adult patients with rheumatoid arthritis and patients visiting the doctor, at least for the past two months have not had a treatment change. Selected at random from among eligible women 30 -60 years old admitted with mild to moderate range of severity of illness would be a specialist; if DAS (Disease Activity Score) below 3/2 is a mild disease and the DAS (Disease Activity Score) is between 3/2-5/1, moderate severity is defined .
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Determine and compare the clinical improvement in patients with rheumatoid arthritis before and after intervention. Timepoint: Before and 3 month after intervention. Method of measurement: DAS questionnaire.;ADMA concentrations in the serum of patients with rheumatoid arthritis before and three months after the administration of antioxidants. Timepoint: Previous intervention three months after the intervention began. Method of measurement: ELISA method.;Determine changes in serum VEGF rheumatoid arthritis before and three months after the administration of antioxidants. Timepoint: Before and 3 month after intervention. Method of measurement: ELISA. | — |
Secondary
| Measure | Time frame |
|---|---|
| Investigate the effects of antioxidant drugs. Timepoint: Before and three months after intervention. Method of measurement: Questionnaire. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactSousan Kolai
Tabriz University of Medical Sciences
Outcome results
None listed