Downhill running-induced muscle damage. Myalgia
Conditions
Interventions
Intervention 1: Each participant will receive dextrose (5 mg/kg body weight/day) for fourteen consecutive days. After the supplementation period, all subjects will participate in one bout downhill run
Placebo
Treatment - Drugs
Each participant will receive dextrose (5 mg/kg body weight/day) for fourteen consecutive days. After the supplementation period, all subjects will participate in one bout downhill running protocol on
Each participant will receive caffeine (5 mg/kg body weight/day) for fourteen consecutive days. After the supplementation period, all subjects will participate in one bout downhill running protocol on
Sponsors
Graduate office in University of Tabriz
Eligibility
Sex/Gender
Male
Age
22 Years to 28 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria: Healthy males; non-athletes; aged 22-28 years; BMI 18-22 Kg/m2; aerobic power 45-50 ml/kg/min; without any anti-inflammatory and medical drugs such as caffeine>100 mg/day (during 6 months prior to the study). Exclusion criteria: chronic diseases; injuries; and uncontrolled intake of oxidative supplements; uncontrolled intake of anti-inflammatory drugs and stimulants (during the period).
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Total Serum Cereatine kinase (CK). Timepoint: Before and after 14-day supplementation, 30 min before and immediately and 24 hours after downhill running protocol. Method of measurement: Photometric methods with commercial kits (Pars-Azmoon).;C-reacive protein. Timepoint: Before and after 14-day supplementation, 30 min before and immediately and 24 hours after downhill running protocol. Method of measurement: immunoturbidometric assay.;Peripheral blood leukocyte count. Timepoint: Before and after 14-day supplementation, 30 min before and immediately and 24 hours after downhill running protocol. Method of measurement: It will determine by automatic analyzer.;Perceived soreness. Timepoint: Before and after 14-day supplementation, 30 min before and immediately and 24 hours after downhill running protocol. Method of measurement: Talag Scale.;Muscle circumstance. Timepoint: Before and after 14-day supplementation, 30 min before and immediately and 24 hours after downhill running protocol. Method of measurement: It will determine by flexible tap.;Lower limb flexibility. Timepoint: Before and after 14-day supplementation, 30 min before and immediately and 24 hours after downhill running protocol. Method of measurement: Sit and reach test (wells).;Lower limb maximal isometric strength. Timepoint: Before and after 14-day supplementation, 30 min before and immediately and 24 hours after downhill running protocol. Method of measurement: Dynamometric measurement.;Lower limb power. Timepoint: Before and after 14-day supplementation, 30 min before and immediately and 24 hours after downhill running protocol. Method of measurement: Sargent vertical jump test. | — |
Secondary
| Measure | Time frame |
|---|---|
| Maximal Oxygen Consumption. Timepoint: 10 day before supplementation. Method of measurement: It will determine with Bruce treadmill Test.;Body composition. Timepoint: 10 day before supplementation. Method of measurement: It will determine with Skin-fold test (caliper and ACSM’s Formula).;Rating perceived exertion. Timepoint: It will determine at immediately before and after each bout of the exercises. Method of measurement: It will determine by Borg Scale. | — |
Countries
Iran (Islamic Republic of)
Outcome results
None listed