Alzheimer's disease.
Conditions
Interventions
Intervention 1: capsule Saffron 15 mg twice per day for one year. Intervention 2: capsule memantine 10 mg twice per day for one year.
Treatment - Drugs
capsule Saffron 15 mg twice per day for one year
capsule memantine 10 mg twice per day for one year
Sponsors
Tehran University of Medical Sciences
Eligibility
Sex/Gender
All
Age
60 Years to 80 Years
Inclusion criteria
Inclusion criteria: Inclusion Criteria: A diagnosis of Alzheimer’s disease according to the criteria of National Institute of Neurological and Communicative Disorders and Stroke and Alzheimer’s Disease and Related Disorders Association (NINCDS/ADRDA); Presence of severe dementia: MMSE8-14]. Exclusion Criteria: Concomitant diseases such as hypertension, congestive heart failure, non-insulin dependent diabetes mellitus and hypothyroidism; Patients with evidence of other neurodegenerative disorders; Any cardiovascular disease likely to prevent completion of the study; Clinically significant psychiatric diseases; Urinary outflow obstruction; Active peptic ulcer; Any history of epilepsy; Significant drug or alcohol misuse; Drugs with anticholinergic effects or cholinomimetic effects
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Alzheimer's severity. Timepoint: Every month. Method of measurement: SCIRS. | — |
Secondary
| Measure | Time frame |
|---|---|
| Severity of Alzheimer. Timepoint: Every Month. Method of measurement: FAST. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactShahin Akhondzadeh
Tehran University of Medical Sciences
Outcome results
None listed