Lung cancer. Malignant neoplasm of bronchus and lung
Conditions
Interventions
Intervention 1: Control group: Standard protocol of anesthesia and surgery. Intervention 2: Intervention group: MgSO4 administration
in addition to standard cares, administration of MgSO4 made by Karmania Pars gene (KPG) company is added during induction of anesthesia (40 mg/kg within 10 minutes) and then infusion of maintenance do
Sponsors
Cancer institute
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: Patients with stage I (cT1N0 and cT2N0), stage II (cT1N1, cT2N1 and cT3N0) lung cancer Age 18 to 65 years old Candidate for lobectomy or pneumoectomy surgery Informed consent
Exclusion criteria
Exclusion criteria: History of severe heart disease, severe systemic and functional lung disease (asthma, COPD) Electrolyte disturbance BMI below 16 concurrent history of other cancers Albumin level less than 5.2 stage IIIA (cT3N1 and cT1–3N2) lung cancer and above Small cell carcinoma HIV positive or any immunodeficiency Patients undergoing clinical trial studies at the same time as this study Dissatisfaction with participating in the study Incomplete tumor resection (potential effect on cytokine levels) Long incision on chest wall, diaphragm or mediastinum Prescribing corticosteroids Pulmonary fibrosis (affected IL-8) History of chemotherapy and radiotherapy during the past month Patients with severe chronic renal failure (creatinine clearance less than 30 ml / min) Patients with acute renal failure and anuria Patients treated with drugs that produce hypermagnesemia (such as spironolactone, eplerenone)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Evaluation of blood levels of inflammatory (IL6, IL8) and anti-inflammatory (IL10, TGF-B) factors in the study groups. Timepoint: A blood sample is collected as a control immediately after induction of anesthesia and then another sample one day after surgery. Method of measurement: Using ELISA test. | — |
Secondary
| Measure | Time frame |
|---|---|
| Mortality rate. Timepoint: At the time of hospitalization up to 6 months after discharge. Method of measurement: Questionnaire. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactMahsa Hamidi Adl
Tehran University of Medical Sciences
Outcome results
None listed