Ulcerative colitis. Ulcerative colitis
Conditions
Interventions
Intervention 1: Intervention group: This group will receive colon specific tablets at the dose of 400 mg dried extract of Malva sylvestris, twice a day for 1 months, in adjunct to the routine treatmen
Sponsors
Shiraz University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: Medium or mild left sided colitis
Exclusion criteria
Exclusion criteria: Age under 18 and over 70 years Addiction Unwillingness to attend or continue to study pregnacy history of allergy to common mallow Taking prednisolone above 15 mg daily and/or cyclosporine and/or infliximab within a month before intervention Taking CNi; anti TNF; 6 MP or any antibiotics within a month before intervention suffering from other inflammatory or non-infammatory bowel diseases such as neoplasms (observation of dysplasia in the tissue samples), polyposis, etc.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| C-reactive protein (C-RP) level. Timepoint: Before intervention and four weeks after intervention initiation. Method of measurement: Laboratory test.;Level of calpertectin in patients stool sample. Timepoint: Before intervention and four weeks after intervention initiation. Method of measurement: EISA Kit. | — |
Secondary
| Measure | Time frame |
|---|---|
| Quality of life. Timepoint: Before and four weeks after intervention initiation. Method of measurement: Through the Inflammatory Bowel Disease Quality of Life Questionnaire (IBDQOL).;Complete blood count (CBC). Timepoint: Before and four weeks after intervention initiation. Method of measurement: Laboratory test.;Level of IL-6 in patients serum. Timepoint: Before and four weeks after intervention initiation. Method of measurement: ELISA Kit. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactDr. Azadeh Hamedi
Shiraz University of Medical Sciences
Outcome results
None listed