Parkinson disease. Parkinson's disease
Conditions
Interventions
Intervention 1: Intervention group: Treatment group will receive polyphenol rich extract of licorice at the dose of 136 mg/ 5cc syrup, twice a day for 6 months, in adjunct to the routine treatment of
Sponsors
Shiraz University of Medical Sciences
Eligibility
Sex/Gender
All
Age
30 Years to 80 Years
Inclusion criteria
Inclusion criteria: Age between 30 to 80 years idiopathic parkinson disease (PD) initiation of PD symptoms in recent 6 years The modified Hoehn and Yahr Scale: staging = 3 no treatment changes within 4 weeks before starting the intervention
Exclusion criteria
Exclusion criteria: Consumption of warfarin; selective serotonin reuptake inhibitors (SSRI), Monoamine oxidase inhibitors (MAOIs), or diuretic History of stroke; myocardial infarction; heart failure; renal failure or cardiac arrhythmia Uncontrolled hypertension and hypokalemia pregnant and lactating women Liver diseases Diabetes complication of treatment including urticaria, pruritis, nasea and vomiting and vertigo
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Unified Parkinson’s Disease Rating Scale (UPDRS). Timepoint: First visit and every 6-8 weeks up to 6 months after intervention began. Method of measurement: Examination by the neurologist physician and Rating the diseases scale based on the Unified Parkinson's Disease Rating Scale (UPDRS). | — |
Secondary
| Measure | Time frame |
|---|---|
| Patients electrolytes level. Timepoint: At the beginning of the study and every 6-8 weeks for six months after the intervention began. Method of measurement: Serologic tests.;Patients blood pressure. Timepoint: At the beginning of the study and every 6-8 weeks for six months after the intervention began. Method of measurement: Measurement by the physician with a blood pressure monitor. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactDr. Azadeh Hamedi; Dr.Peyman Petramfar
Shiraz University of Medical Sciences
Outcome results
None listed