Condition 1: head and neck malignancecies. Condition 2: Mucositis. Malignant neoplasms of lip, oral cavity and pharynx Radiation-related disorders of the skin and subcutaneous tissue
Conditions
Interventions
Intervention 1: The bottles containing 100 cc aqueous Glycyrrhiza extract 50% was given to every patient and ask them to use 2 cc twice per day for 14 days after starting radiotherapy. Intervention 2:
Treatment - Drugs
Placebo
The bottles containing 100 cc aqueous Glycyrrhiza extract 50% was given to every patient and ask them to use 2 cc twice per day for 14 days after starting radiotherapy.
The bottles containing 100 cc liquid as placebo was given to every patient and ask them to use 2 cc twice per day for 14 days after starting radiotherapy.
Sponsors
Mrs zolfaghari
Eligibility
Sex/Gender
All
Age
18 Years to 149 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria: Patients should be at least 18 years old; There should be definite diagnosis of head and neck cancer for patients; Radiation therapy dose determined by patient’s radiotherapist should be at least 50 Gy (the average dose that often cause mucositis); Patient should have the ability of using extract before every radiotherapy session; At least 50% mouth cavity should be in ray field (diagnosed by radiotherapy expert). Exclusion criteria: Patients who are now under radiotherapy for head and neck cancer and or have received every type of treatment and ray therapy for head and neck cancer in recent year. Patients with allergic history to glycyrrhiza. Patients who may show complications to medicine. Patients who couldn’t use aqueous glycyrrhiza extract in their mouth on the base of their verdict or their examiner’s saying.Patients who had every type of mouth problem for example active infection, wound and etc. Before starting radiotherapy. Patient’s announcement of not cooperating in every step of project.
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Burning mouth. Timepoint: The first day and at the end of 14. Method of measurement: visual scale.;Wound size. Timepoint: The first day and at the end of 14. Method of measurement: Scaled graph paper. | — |
Secondary
| Measure | Time frame |
|---|---|
| Drug interactions with analgesic drugs of patients. Timepoint: 1week. Method of measurement: visual scale.;Licorice sensitivity. Timepoint: 14 days. Method of measurement: Observability and Question. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactDr Shamsolmolok Najafi
Tehtan University of Medical Siense
Outcome results
None listed