Condition 1: breast cancer. Condition 2: Breast cancer. Breast, unspecified CD50.0,50.1,50.2,50.3,50.4,50.5,50.6
Conditions
Interventions
Intervention 1: tamoxifen+exercise trianing. Intervention 2: tamoxifen without exercise trianing. Intervention 3: letrozole with exercise training. Intervention 4: letrozole without exercise trianing
Lifestyle
Treatment - Drugs
tamoxifen+exercise trianing
tamoxifen without exercise trianing
letrozole with exercise training
letrozole without exercise trianing
Sponsors
Research Deputy of Tehran University of Medical Sciences
Eligibility
Sex/Gender
Female
Age
30 Years to 60 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria:Female;-Pathology report of invasive breast carcinoma;ER positive primary tumor;adequate renal,liver,lung and cardiac function;signed informed consent ;at least one month after end of adjuvant therapy(surgery,chemotherapy and radiotherapy);hormonal therapy Exclusion criteria:Age under 30 or over 60; Metastatic disease;Under invasive therapy(chemo-radiotherapy);Hormone receptor negative(non luminal);Less than 50%heart ejection fraction,ischemic heart disease,COPD, liver failure(liver enzimes more than 5 times of upper normal limit) or creatinine more than 2 mg/dl
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Effects of an interval exercise training on blood immune parameters(HSP70, INF-y, IL-4, IL-1ß, TNF-a, IL-6, CD4, CD8, and cortisol )of patients on hormonal therapy. Timepoint: before and after 12 weeks trianing. Method of measurement: measurment of parameters by using ELISA kit. | — |
Secondary
| Measure | Time frame |
|---|---|
| Evaluation of an interval exercise training on physical fitness,body fat,strength and flexibility of patients on tamoxifen therapy. Timepoint: before after 12 weeks training. Method of measurement: using caliper,halter and VO2max formula after one mile walking.;Effects of an interval exercise training program with letrozol on quality of life of patients. Timepoint: before after 12 weeks training. Method of measurement: QOL questionnaire(FACT).;Effects of an interval exercise training program with tamoxifen on quality of life of patients. Timepoint: before after 12 weeks training. Method of measurement: QOL questionnaire(FACT-B).;Evaluation of an interval exercise training on physical fitness,body fat,strength and flexibility of patients on tamoxifen therapy. Timepoint: before after 12 weeks training. Method of measurement: one mile walking and measuring VO2max,caliper,halter.;Effects of an interval exercise training program with tamoxifen on rehabilitization of the patient. Timepoint: before after 12 weeks training. Method of measurement: CARES questionnaire.;Effects of an interval exercise training program with letrozole on rehabilitization of the patient. Timepoint: before after 12 weeks training. Method of measurement: CARES questionnaire. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public Contactalimohamad alizadeh
cancer institute
Outcome results
None listed