Upper gastro intestinal bleeding. Diseases of oesophagus, stomach and duodenum
Conditions
Interventions
Intervention 1: Pantoprazole 80 mg bolus infusion followed by 8 mg/h intravenously as maintenance dose for 72 h after endoscopic treatment. Intervention 2: Pantoprazole 80 mg bolus infusion followed b
Treatment - Drugs
Pantoprazole 80 mg bolus infusion followed by 8 mg/h intravenously as maintenance dose for 72 h after endoscopic treatment
Pantoprazole 80 mg bolus infusion followed by 4 mg/h intravenously as maintenance dose for 72 h after endoscopic treatment
Sponsors
Research Deputy of Ahvaz University of Medical Sciences
Eligibility
Sex/Gender
All
Age
16 Years to 70 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria: patients who admit and present signs and symptoms of upper gastrointestinal bleeding such as: 1-Vomits of blood or black material (Hematemesis), 2-Black and tarry stool (Melena), 3-The passage of bright red or blood from the rectum (Hematochesia), 4-Vertigo; light headness and hypotension. Exclusion criteria are: 1-Malignant ulcer; 2-Multiple ulcers; 3-Cirrhotic patient with coagulopathy or hemorrhagic varices; 4-Chronic Renal Failure (CRF); 5-Patients who admitted with gastrointestinal bleeding in last month; 6-Patients receive NSAID and Corticosteroid for underlying disease; 7-Patients under 16 years or upper 70 years;8-Patients who are treated with PPI (proton pomp inhibitor) in last week.
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Mean units of blood transfusde. Timepoint: In period of admission. Method of measurement: Mean units of blood transfusde in period of admission.;Duration of admission more than 5 days. Timepoint: In period of admission. Method of measurement: This time evaluate from admission to discharge.;Need for surgery. Timepoint: In period of admission. Method of measurement: According to vital signs and hemodinamicaly status.;Rebleeding. Timepoint: In period of admission. Method of measurement: According to vital signs and hemodinamicaly status. | — |
Secondary
| Measure | Time frame |
|---|---|
| Readmission due to upper gastrointestinal bleeding. Timepoint: First month after admission. Method of measurement: With take of history and hemodinamicaly status.;The mortality rate. Timepoint: First month of admission. Method of measurement: With take of history and hemodinamicaly status. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactNoorodin Jamshydian
Ahvaz Jundishapur University of Medical Sciences
Outcome results
None listed