Major Depression.
Conditions
Interventions
Intervention 1: Saffron Capsule maximum 30 mg/day for six weeks. Intervention 2: Fluoxetine Capsule maximum 40 mg/day for six weeks.
Treatment - Drugs
Saffron Capsule maximum 30 mg/day for six weeks
Fluoxetine Capsule maximum 40 mg/day for six weeks
Sponsors
Tehran University of Medical Sciences
Eligibility
Sex/Gender
All
Age
20 Years to 65 Years
Inclusion criteria
Inclusion criteria: Inclusion: 1. Patients underwent angioplasty 2. Have depression based on DSM-IV-TR and score of 14-22 on Hamilton Depression Rating Scale 3. Informed consent Exclusion : 1.Psychosis 2. Current use of other psychotropic agents 3.Antidepressant in the last month 4.ECT in the previous two months 5- Thyroid problem 6.Lactation and pregnancy 7. Problems in other DSM axes 8.History of substance abuse or dependence during the last three months 9. High risk of suicide 10. Oral contraception use 11. Women of child-bearing if willing to be pregnant 12.Need for unusual psychiatric treatment
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Severity of Depressive symptoms. Timepoint: Weeks 0, 3 and 6. Method of measurement: Hamilton Depression Rating Scale-17 item. | — |
Secondary
| Measure | Time frame |
|---|---|
| Side effects. Timepoint: Weeks 1, 3 and 6. Method of measurement: Side-effect Checklist. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactShahin Akhondzadeh
Tehran University of Medical Sciences
Outcome results
None listed