Comparison of efficacy and complications of Nasal intermittent positive pressure ventilation (NIPPV) and nasal continuous positive airway pressure (NCPAP) in preterm infants

Comparison of efficacy and complications of NIPPV vs NCPAP in preterm infants with respiratory distress admitted in NICU

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT201202273250N6

Enrollment

120

Registered

2012-03-12

Start date

2012-03-20

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

respiratory distress in neonates. Respiratory distress syndrome of newborns

Interventions

Intervention 1: Intervention: ventilatory NIPPV. Intervention 2: Intervention: ventilatory NCPAP.

Treatment - Devices

Intervention: ventilatory NIPPV

Intervention: ventilatory NCPAP

Eligibility

Sex/Gender

All

Age

No minimum to 1 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: All consecutively born preterm infants with gestational age 28 to 36 weeks, admitted to Afzalipour neonatal intensive care unit with respiratory distress and silverman- Anderson retraction score of 6 and 7. Exclusion criteria: Babies were excluded if there was signiicant morbidity apart from RDS including cardiac disease, congenital malformation including congenital diapheragmatic hernia, tracheoeso phageal fistula and cleft lip/palate, babies with respiratory distress secondary to severe asphyxia (Apgar score <3 at 1 and 5 minute or PH<7/12 or if they had cardiovascular or respiratory instability because of sepsis, anemia or severe intraventriculare hemorrhage (IVH) on admission.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Response to treatment. Timepoint: During hospitalization and using NCPAPand NIPPV. Method of measurement: comparing survival rates.	—

Secondary

Measure	Time frame
Incidence of pneumothorax. Timepoint: During hospitalization and using NCPAPand NIPPV. Method of measurement: Taking chest x rays on admission and deterioration of clinical status.;Incidence of PDA. Timepoint: During hospitalization and using NCPAPand NIPPV. Method of measurement: Echo cardiography on admission and deterioration of clinical status.;Incidence of IVH. Timepoint: During hospitalization and using NCPAPand NIPPV. Method of measurement: Cranial ultra sonography on admission and deterioration of clinical status.	—

Measure

Time frame

Incidence of pneumothorax. Timepoint: During hospitalization and using NCPAPand NIPPV. Method of measurement: Taking chest x rays on admission and deterioration of clinical status.;Incidence of PDA. Timepoint: During hospitalization and using NCPAPand NIPPV. Method of measurement: Echo cardiography on admission and deterioration of clinical status.;Incidence of IVH. Timepoint: During hospitalization and using NCPAPand NIPPV. Method of measurement: Cranial ultra sonography on admission and deterioration of clinical status.

—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactReza Mahdian Jouybari

Kerman University of Medical Sciences

reza.mj98@yahoo.com+98 341322225060

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026