Efficacy of dexamethasone, IV-IG and Interferone beta for treatment of patients with severe COVID-19

Efficacy of different methods of administeration of combination regiemn including dexamethasone, IV-IG and Interferone beta for treatment of patients with severe COVID-19: a randomized controlled trial

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20120225009124N4

Enrollment

105

Registered

2020-04-02

Start date

2020-04-18

Completion date

Unknown

Last updated

2020-04-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

COVID-19. COVID-19, virus identified

Interventions

Intervention 1: Control group: Receive standard treatment for COVID19 according to the protocol of MOH of Iran (antiviral drugs and hydroxychloroquine). Intervention 2: Intervention group 1: Receive s

Eligibility

Sex/Gender

All

Age

18 Years to 70 Years

Inclusion criteria

Inclusion criteria: Age 18-70 years Sever COVID19 disease with the following criteria: SPpO2 below 90% and respiratory rate higher 24 per minute; Involvement of more that 50% of lung in CT-scan

Exclusion criteria

Exclusion criteria: Need for intubation at the time of admission Contraindication of corticosteroids, IV IG and interferon beta Pregnancy, lactation

Design outcomes

Primary

Measure	Time frame
Improvement in SpO2 (increasing in level of SpO2 to levels higher than 90%). Timepoint: After finishing the intervetion. Method of measurement: By Pulse oximeter.	—

Secondary

Measure	Time frame
Duration of stay in hospital. Timepoint: After finishing the intervention. Method of measurement: Reviewing patient hospital file.;Intubation. Timepoint: After finishing the intervention. Method of measurement: Reviewing patient hospital file.;Mortality. Timepoint: After finishing the intervention. Method of measurement: Reviewing patient hospital file.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr Nafiseh Abdolahi

Gorgan University of Medical Sciences

n_abdolahi2002@yahoo.com+98 17 3225 1910

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 27, 2026