schizophrenia. schizophrenia
Conditions
Interventions
Intervention 1: Tablets Risperidone (6 mg/day) combined with 200mg/day Minocycline as intervention group for 8 weeks. Intervention 2: Tablet Risperidone (6 mg/day) combined with placebo as control gro
Treatment - Drugs
Placebo
Tablets Risperidone (6 mg/day) combined with 200mg/day Minocycline as intervention group for 8 weeks
Sponsors
Tehran University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 50 Years
Inclusion criteria
Inclusion criteria: Inclusion Criteria: Age between 18-50; Diagnosis of Schizophrenia based on DSM IV; chronic Schizophrenia( duration of the disorder>2 years); Stable on antipsychotics Exclusion Criteria: Substance dependence; IQ <70; any other mental disorder on axis I; Any serious medical or neurological problem ; receiving oral antipsychotic medications during the last week or receiving any depot antipsychotic medication during the last month; receiving ECT during the last 14 days; hepatic disease
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Severity of schizophrenia. Timepoint: Baseline and weeks 2-4-6-8 after beginig of treatment. Method of measurement: Positive and Negative Syndrome Scale (PANSS). | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactProf. Shahin Akhondzadeh
Tehran University of Medical Sciences
Outcome results
None listed