congenital heart disease circulatory disease. Other functional disturbances following cardiac surgery
Conditions
Interventions
sildenafil 0.5mg/kg/q8hours for one week.
Treatment - Drugs
sildenafil 0.5mg/kg/q8hours for one week
Sponsors
Tehran University of Medical Sciences
Eligibility
Sex/Gender
All
Age
8 Years to 35 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria: patients aged =8 years with Fontan modification of ECTCPC, patients had NYHA function class of I , being stable for the past 6 months without the occurrence of new symptoms or any changes in their medication. Exclusion criteria: pulse oxymetry of <80%, systolic blood pressure of <75 mmHg, hepatic and renal dysfunction confirmed by laboratory examination, ophthalmic and auditory defect, hypersensivity to sildenafil, Fontan pathway obstruction detected by CT/MR imaging or angiography and recent use of sildenafi in the past 3 months, patients with residual cardiovascular defects such as coarctation, cardiac dysrhythmia or bradycardia, pregnant patients
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Elastance. Timepoint: at the onset and one week post sildenafil administration. Method of measurement: echocardiography. | — |
Secondary
| Measure | Time frame |
|---|---|
| Headache, flushing,vertigo,nausea and vomiting, abdominal pain, renal stone, photosensivity,rash,diarrhea ,hypotension, musle pain,tinnitus. Timepoint: at the onset and one week post sildenafil administration and surviellance of side effects during the one week period of study. Method of measurement: queries. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactReza Shabanian
Cildren's Medical Center
Outcome results
None listed