Skip to content

Evaluating the effect of drug therapy on neonatal icter

Comparing the effect of clofibrate and Phenobarbital on bilirubin level, hospitalization and phototherapy period in icteric non hemolytic newborns

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
IRCT
Registry ID
IRCT201202199073N1
Enrollment
90
Registered
2012-07-05
Start date
2012-04-03
Completion date
Unknown
Last updated
2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Icteric non-hemolitic newborns. Neonatal jaundice, unspecified

Interventions

Intervention 1: Group1: prescribed 100 mg /kg clofibrate orally as single dose on arrival, in addition to phototerapy for 3 days. Intervention 2: Group 2: prescribed 5 mg /kg phenobarbital orally as
Treatment - Drugs
Placebo
Group1: prescribed 100 mg /kg clofibrate orally as single dose on arrival, in addition to phototerapy for 3 days.
Group 2: prescribed 5 mg /kg phenobarbital orally as single dose on arrival, in addition to phototerapy for 3 days.
Group 3: only reseaved distrilled water in addition to phototherapy for 3 days.

Sponsors

Shahrekord University of Medical Science
Lead Sponsor

Eligibility

Sex/Gender
All
Age
No minimum to 1 Years

Inclusion criteria

Inclusion criteria: Iinclusion criteria:Parents permission; Infants with non-hemolytic icter; term neonates (37-42 weeks age); birth weight 2/5- 4kg; breast feeding only; indirect bilirubin level between 15-20 mg/dl on arrival; jaundice beginning at days 3-11 after birth; hematocrit level less than 65% or Hb under 20 Exclusion criteria: physical anomalies; previous remedy consumption; previous history of jaundice therapy; sepsis

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

MeasureTime frame
Serum bilirubin level. Timepoint: On arival and 12, 24, 48 and 72 hours after. Method of measurement: mg/dl.

Secondary

MeasureTime frame
Duration of hospitalization. Timepoint: Day. Method of measurement: Days beeing hospitalized.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr. Majid Hamidi

Shahrekord University of Medical Science

majid_hamidi48@yahoo.com+381 22 20016

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026