Condition 1: Rheumatoid arthritis. Condition 2: Rheumatoid arthritis. Other rheumatoid arthritis Seropositive rheumatoid arthritis
Conditions
Interventions
Intervention 1: Placebo(2 capsules) intake per day, for 2 months. Intervention 2: Pomegranate supplement(2 capsules) intake is equivalent to 500 mg per day, for 2 months.
Placebo
Treatment - Drugs
Placebo(2 capsules) intake per day, for 2 months
Pomegranate supplement(2 capsules) intake is equivalent to 500 mg per day, for 2 months
Sponsors
Vice chancellor for research OF Shiraz university of medical sciences
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria: Rheumatoid arthritis patients which their disease diagnosed according to the revised American Rheumatism Association criteria, ages between 18-65 years old, RA patients who don’t have enough clinical and laboratory response to conventional disease modifying anti rheumatic drugs (Methotrexate, Hydroxychloroquine, Sulphasalazine, and prednisolone), No drug type and dose fluctuation since 1 month prior to the study and during intervention period. Exclusion criteria: Presence of Chronic disease such as diabetes, cardiovascular, hepatic, kidney, gastrointestinal diseases, and severe infection, smoking, Alcohol consumption, use of supplements (antioxidants, multivitamins,...), patients with known allergy and food intolerance.
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Disease activity. Timepoint: Before and 2 months after intervention. Method of measurement: DAS 28.;Disability and Pain scales. Timepoint: Before and 2 months after intervention. Method of measurement: health Assessment Questionnaire for Rheumatoid Arthritis patients.;Duration of morning stiffness. Timepoint: Before and 2 months after intervention. Method of measurement: Taking history and Questionnaire. | — |
Secondary
| Measure | Time frame |
|---|---|
| Glutathione peroxidase. Timepoint: Before and 2 months after intervention. Method of measurement: ELIZA kit.;MDA. Timepoint: Before and 2 months after intervention. Method of measurement: Spectrophotometry.;CRP. Timepoint: Before and 2 months after intervention. Method of measurement: ELIZA kit.;ESR. Timepoint: Before and 2 months after intervention. Method of measurement: Westergren.;MMP3. Timepoint: Before and 2 months after intervention. Method of measurement: ELIZA kit. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactElham Tavakoli
School of health & nutrition, Shiraz University of Medical Sciences
Outcome results
None listed