Ventilatory Associated Pneumonia. Aspiration pneumonia (due to): NOS, food, (regurgitated) gastric secretions, milk, vomit
Conditions
Interventions
in intervention group 7 ml hypertonic saline 5% and in control group 7 ml sterile water will be nebulized each 6 hours until the extubated or maximum for 7 days. The patients will be followed for 28 d
Prevention
Sponsors
Tehran University of Medical Sciences
Eligibility
Sex/Gender
All
Age
20 Years to 60 Years
Inclusion criteria
Inclusion criteria: inclusion criteria: intubation period less than 24 hour, no clinical and imaging manifestation of pneumonia exclusion criteria: pulmonary infection; Acute physiology and chronic health evaluation II score II>25; active infection in admission; evidence of infection in chest X ray; immune deficiency; prescribe of high dose cortocosteroid (more than 300mg hydrocortisone); advanced cancer.
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Pneumonia. Timepoint: 0, 48, 72, 120 and 144 hour after start of study. Method of measurement: physical exam,chest x ray, culture of tracheal secretion. | — |
Secondary
| Measure | Time frame |
|---|---|
| Level of Interlukin- 6 levelof trachea secretions and blood. Timepoint: 0, 48,72,120 and 144 hour after start of study. Method of measurement: ELIZA. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactDr. Mohammad Taghi Beigmohammadi
Tehran University of Medical Sciences
Outcome results
None listed