Adipose Cell Derived Stem Cell application in deep burn healing

Regeneration of human skin by adipose-derived stem cells (ADSC) cultured on scaffold

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT201202169044N1

Enrollment

Registered

2012-07-05

Start date

2012-07-22

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Deep Burn. Burn of third degree of trunk

Interventions

Intervention 1: Intervention: Prepared scaffold with ADSCs processed from autologous fat are applied in the burn wounds covered by a silicon sheet and would healing would be monitored then after. I

Treatment - Surgery

Intervention: Prepared scaffold with ADSCs processed from autologous fat are applied in the burn wounds covered by a silicon sheet and would healing would be monitored then after.

Control : Prepared scaffold without ADSCs in control group is applied in the burn wounds and covered by a silicon sheet .

Eligibility

Sex/Gender

All

Age

15 Years to 50 Years

Inclusion criteria

Inclusion criteria: Inclusion criterion: third degree deep burn patients with less than 30% TBSA involvement. Exclusion criteria: 1. Non thermal burns and association with inhalation injury. 2. Patients below 15 y and above 50 y. 3. Diabetics and those with systemic conditions that impairs wound healing. 4. Multiple organ failure (respiratory, renal, etc...). 5. Wound infection. 6. SIRS : Include: fever >38c or hypothermia. >36c ,.Tachycardia >90 ppm, locoytosis WBC>4000 or Locopenia 10%.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Vascularization. Timepoint: At the en of third week. Method of measurement: Number of blood vessels counted by digital camera in milimeter.;Collagen Number. Timepoint: At the end of third week. Method of measurement: Counting collagen bundles under microscope.;Collagen maturity. Timepoint: At the end of third week. Method of measurement: Ratio of mature collagen bundles to the whole collagen in the wound garding in low, moderate, high.;Granulation. Timepoint: at the end of third week. Method of measurement: Fibroplasia and angiogenesis in the wound beed grading in low, moderate and high.;Epithelialization. Timepoint: At the end of third week. Method of measurement: Epithelialization density is graded in low , moderate and high.;Inflamation. Timepoint: At the end of third week. Method of measurement: Inflamatory cells infiltration density garding in low, modarate and high.;Graft take. Timepoint: 1, 3 and 12 week. Method of measurement: Clinical judgment.	—

Measure

Time frame

Vascularization. Timepoint: At the en of third week. Method of measurement: Number of blood vessels counted by digital camera in milimeter.;Collagen Number. Timepoint: At the end of third week. Method of measurement: Counting collagen bundles under microscope.;Collagen maturity. Timepoint: At the end of third week. Method of measurement: Ratio of mature collagen bundles to the whole collagen in the wound garding in low, moderate, high.;Granulation. Timepoint: at the end of third week. Method of measurement: Fibroplasia and angiogenesis in the wound beed grading in low, moderate and high.;Epithelialization. Timepoint: At the end of third week. Method of measurement: Epithelialization density is graded in low , moderate and high.;Inflamation. Timepoint: At the end of third week. Method of measurement: Inflamatory cells infiltration density garding in low, modarate and high.;Graft take. Timepoint: 1, 3 and 12 week. Method of measurement: Clinical judgment.

—

Secondary

Measure	Time frame
Wound infection. Timepoint: 1, 3 and 12 week. Method of measurement: Appearance of wound.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactKamran Asadi

Hazrat Fatemeh Hospital

asadi_kamran@tums.ac.ir+98 21 8871 7272

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026