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Phytochemical and clinical effect of a herbal medicine containing mint, rosemary, lavender, and clove compared to placebo on the prevention and control of migraine symptoms

Phytochemical and clinical effect of a herbal medicine containing mint, rosemary, lavender, and clove compared to placebo on the prevention and control of migraine symptoms: a triple-blind randomized clinical trial

Status
Active, not recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20120215009014N611
Enrollment
155
Registered
2026-05-19
Start date
2026-06-22
Completion date
Unknown
Last updated
2026-06-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Migraine. Migraine

Interventions

Intervention 1: Intervention group 1: Routine treatment plus herbal medicine containing mint applied as local massage on the temples, neck, forehead, and behind the ears three times per week for one m

Sponsors

Hamedan University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 55 Years

Inclusion criteria

Inclusion criteria: Age 18 to 55 years, Diagnosis of migraine, Experience of at least 4 migraine attacks in the past three months,

Exclusion criteria

Exclusion criteria: Use of similar herbal medicines in the past 2 months, Pregnancy or breastfeeding, Presence of other neurological disorders such as epilepsy or multiple sclerosis, Use of antidepressant or anticonvulsant medications in the past 2 months

Design outcomes

Primary

MeasureTime frame
Number of migraine attacks. Timepoint: Before intervention and one month later. Method of measurement: By medical history.;Headache severity. Timepoint: Before intervention and one month later. Method of measurement: Using the Visual Analogue Scale (VAS).;Mean duration of migraine attacks. Timepoint: Before intervention and one month later. Method of measurement: By medical history.

Secondary

MeasureTime frame
Improvement in sleep quality. Timepoint: Before intervention and one month later. Method of measurement: Using the Pittsburgh Sleep Quality Index (PSQI).;Amount of analgesic medication use. Timepoint: before intervention and one month later. Method of measurement: By medical history.;Mean mood and anxiety score. Timepoint: before intervention and one month later. Method of measurement: Using the Depression Anxiety Stress Scales - 21 (DASS-21).;Mean patient satisfaction score. Timepoint: Before intervention and one month later. Method of measurement: Using a researcher-designed questionnaire.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDorsa Mahdizade

Hamedan University of Medical Sciences

mahdizadedorsa1379@gmail.com+98 81 3838 0572

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Jun 11, 2026