Effect of coenzyme Q10 supplementation on oxidative stress, inflammation, hematology, liver and kidney profiles in organophosphate poisoned patients

Effect of coenzyme Q10 supplementation on oxidative stress, inflammation, hematology, liver and kidney profiles in organophosphate poisoned patients: a single-blind randomized clinical trial

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20120215009014N610

Enrollment

Registered

2026-05-15

Start date

2026-05-31

Completion date

Unknown

Last updated

2026-06-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Organophosphate poisening. Toxic effect of organophosphate and carbamate insecticides

Interventions

Intervention 1: Intervention group: Routine treatment for organophosphate poisoning plus one coenzyme Q10 supplement, 100 mg twice daily, for one week. Intervention 2: Control Group: Routine treatment

Eligibility

Sex/Gender

All

Age

20 Years to 40 Years

Inclusion criteria

Inclusion criteria: Age of 20 to 40 years, Poisoned with organophosphate

Exclusion criteria

Exclusion criteria: Swallowing disorders

Design outcomes

Primary

Measure	Time frame
Lipid peroxidation level. Timepoint: Before the intervention and one week after the intervention. Method of measurement: Using TBA reagent at a wavelength of 532 nm by a spectrophotometer.;Total blood antioxidant capacity. Timepoint: Before the intervention and one week after the intervention. Method of measurement: Using TPTZ reagent at a wavelength of 593 nm by a spectrophotometer.;Blood thiol group levels. Timepoint: Before the intervention and one week after the intervention. Method of measurement: Using DTNB reagent at a wavelength of 412 nm by a spectrophotometer.;Catalase enzyme activity. Timepoint: Before the intervention and one week after the intervention. Method of measurement: Using H2O2 reagent and sodium phosphate buffer at a wavelength of 240 nm by a spectrophotometer.;CRP level. Timepoint: Before the intervention and one week after the intervention. Method of measurement: By collecting and testing a blood sample.;ESR level. Timepoint: Before the intervention and one week after the intervention. Method of measurement: By collecting and testing a blood sample.;WBC level. Timepoint: Before the intervention and one week after the intervention. Method of measurement: By collecting and testing a blood sample.;RBC level. Timepoint: Before the intervention and one week after the intervention. Method of measurement: By collecting and testing a blood sample.;Hemoglobin level. Timepoint: Before the intervention and one week after the intervention. Method of measurement: By collecting and testing a blood sample.;Triglyceride level. Timepoint: Before the intervention and one week after the intervention. Method of measurement: By collecting and testing a blood sample.;LDL level. Timepoint: Before the intervention and one week after the intervention. Method of measurement: By collecting and testing a blood sample.;HDL level. Timepoint: Before the intervention and one week after the intervention. Method of measurement: By collecting and testing a blood sample.;Urea	—

Measure

Time frame

Lipid peroxidation level. Timepoint: Before the intervention and one week after the intervention. Method of measurement: Using TBA reagent at a wavelength of 532 nm by a spectrophotometer.;Total blood antioxidant capacity. Timepoint: Before the intervention and one week after the intervention. Method of measurement: Using TPTZ reagent at a wavelength of 593 nm by a spectrophotometer.;Blood thiol group levels. Timepoint: Before the intervention and one week after the intervention. Method of measurement: Using DTNB reagent at a wavelength of 412 nm by a spectrophotometer.;Catalase enzyme activity. Timepoint: Before the intervention and one week after the intervention. Method of measurement: Using H2O2 reagent and sodium phosphate buffer at a wavelength of 240 nm by a spectrophotometer.;CRP level. Timepoint: Before the intervention and one week after the intervention. Method of measurement: By collecting and testing a blood sample.;ESR level. Timepoint: Before the intervention and one week after the intervention. Method of measurement: By collecting and testing a blood sample.;WBC level. Timepoint: Before the intervention and one week after the intervention. Method of measurement: By collecting and testing a blood sample.;RBC level. Timepoint: Before the intervention and one week after the intervention. Method of measurement: By collecting and testing a blood sample.;Hemoglobin level. Timepoint: Before the intervention and one week after the intervention. Method of measurement: By collecting and testing a blood sample.;Triglyceride level. Timepoint: Before the intervention and one week after the intervention. Method of measurement: By collecting and testing a blood sample.;LDL level. Timepoint: Before the intervention and one week after the intervention. Method of measurement: By collecting and testing a blood sample.;HDL level. Timepoint: Before the intervention and one week after the intervention. Method of measurement: By collecting and testing a blood sample.;Urea

—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr Freshteh Mehri

Hamedan University of Medical Sciences

freshteh_mehri@yahoo.com+98 81 3838 0572

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Jun 11, 2026