Effect of propolis, clove, and chlorhexidine mouthwashes on oral hygiene and prevention of ventilator-associated pneumonia in the intensive care unit

Effect of propolis, clove, and chlorhexidine mouthwashes on oral hygiene and prevention of ventilator-associated pneumonia in the intensive care unit: a single-blind randomized clinical trial

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20120215009014N597

Enrollment

168

Registered

2026-02-18

Start date

2026-03-06

Completion date

Unknown

Last updated

2026-06-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Ventilator associated pneumonia. Ventilator associated pneumonia

Interventions

Intervention 1: Intervention group 1: All areas of the mouth, including the inner and outer surfaces of the teeth (with circular movements), gums, and tongue (with back-to-front movements), will be br

Eligibility

Sex/Gender

All

Age

18 Years to 75 Years

Inclusion criteria

Inclusion criteria: Age 18 to 75 years, Intensive care unit hospitalization, Having an orotracheal tube, Having a nasogastric tube, Less than 48 hours have passed since the patient was hospitalized,

Exclusion criteria

Exclusion criteria: Immune system disorder, Having a pulmonary infection during hospitalization, Being a smoker

Design outcomes

Primary

Measure	Time frame
Ventilator-associated pneumonia. Timepoint: Before intervention and on the sixth day of intervention. Method of measurement: Using the Mucosal Plaque Score Index (MCPIS).;Oral hygiene. Timepoint: Before intervention and on the sixth day of intervention. Method of measurement: Using the Beck Oral Assessment Scale (BOAS).	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactSeyed Erfan Soltani

Hamedan University of Medical Sciences

erfansoltani903@gmail.com+98 81 3838 0572

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Jun 11, 2026