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Effect of topical diclofenac sodium versus cryotherapy on treatment of patients with seborrheic keratosis

Effect of topical diclofenac sodium versus cryotherapy on treatment of patients with seborrheic keratosis: a randomized clinical trial

Status
Active, not recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20120215009014N595
Enrollment
24
Registered
2026-02-11
Start date
2026-03-06
Completion date
Unknown
Last updated
2026-06-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Seborrheic keratosis. Seborrheic keratosis

Interventions

Intervention 1: Intervention group 1: Cryotherapy treatment (placing a cotton swab soaked in liquid nitrogen on the seborrheic keratosis lesions with a margin of 1 to 2 mm of healthy skin around it un

Sponsors

Hamedan University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 75 Years

Inclusion criteria

Inclusion criteria: Age 18 to 75 years, At least 2 seborrheic keratosis lesions of similar size and diameter,

Exclusion criteria

Exclusion criteria: Pregnancy or breastfeeding Presence of wound or active skin disease at the treatment site, Seborrheic keratosis lesions on the eyelid or around the eye, Cold urticaria and any type of cold rash, Cryoglobulinemia, Skin reaction to NSAID

Design outcomes

Primary

MeasureTime frame
Shape and size of seborrheic keratosis lesions. Timepoint: Before intervention and at 2, 4, 6 and 8 weeks after intervention. Method of measurement: By clinical examination.;Mean treatment satisfaction score. Timepoint: 8 weeks after intervention. Method of measurement: Using a standard treatment satisfaction questionnaire.

Secondary

MeasureTime frame
Local complications (redness, itching, hives). Timepoint: At 2, 4, 6 and 8 weeks after intervention. Method of measurement: By history taking and physical examination.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr. Maryam Hesaminia

Hamedan University of Medical Sciences

maryamhesaminia@gmail.com+98 81 3838 0572

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Jun 11, 2026