Effect of prophylactic antibiotic versus control group on clinical signs after appendectomy in acute appendicitis

Effect of prophylactic antibiotic versus control group on clinical signs after appendectomy in acute appendicitis: a single-blind randomized clinical trial

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20120215009014N594

Enrollment

150

Registered

2026-01-27

Start date

2026-02-20

Completion date

Unknown

Last updated

2026-02-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Acute appendicitis. Acute appendicitis

Interventions

Intervention 1: Intervention group: Routine appendectomy treatment plus antibiotic administration one hour before surgery including cefazolin 1 gram and metronidazole 500 mg and also postoperatively c

Eligibility

Sex/Gender

All

Age

18 Years to 65 Years

Inclusion criteria

Inclusion criteria: Age 18 to 65 years, Acute perforated appendicitis,

Exclusion criteria

Exclusion criteria: Pregnancy, Consumption of any antibiotic within 48 hours before surgery

Design outcomes

Primary

Measure	Time frame
Occurrence of fever. Timepoint: In the first 24 hours after surgery. Method of measurement: By clinical examination.;Occurrence of wound dehiscence (deep opening of the skin and fascia). Timepoint: During hospitalization until the day of discharge. Method of measurement: By clinical examination.;Occurrence of wound infection. Timepoint: In the first 24 hours after surgery, at the time of discharge, the second week after surgery, and 1 month after surgery. Method of measurement: By clinical examination.	—

Measure

Time frame

Occurrence of fever. Timepoint: In the first 24 hours after surgery. Method of measurement: By clinical examination.;Occurrence of wound dehiscence (deep opening of the skin and fascia). Timepoint: During hospitalization until the day of discharge. Method of measurement: By clinical examination.;Occurrence of wound infection. Timepoint: In the first 24 hours after surgery, at the time of discharge, the second week after surgery, and 1 month after surgery. Method of measurement: By clinical examination.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr Yashar Fatemi

Hamedan University of Medical Sciences

fatemiyashar56@gmail.com+98 81 3838 0572

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 7, 2026