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Effect of Nicorandil and Ranolazine versus control group on prevention of contrast-induced nephropathy in patients undergoing elective angioplasty

Effect of Nicorandil and Ranolazine versus control group on prevention of contrast-induced nephropathy in patients undergoing elective angioplasty: A double-bind randomized clinical trial

Status
Recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20120215009014N592
Enrollment
180
Registered
2025-12-30
Start date
2026-01-21
Completion date
Unknown
Last updated
2026-02-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Angioplasty. Coronary angioplasty status

Interventions

Intervention 1: Intervention group 1: Intravenous sodium chloride at a rate of 1 ml/kg/hour from 6 hours before angioplasty to 12 hours after that plus oral nicorandil 10 mg, 3 times a day from 1 day

Sponsors

Hamedan University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 80 Years

Inclusion criteria

Inclusion criteria: Age 18 to 80 years, Patients undergoing elective coronary angioplasty,

Exclusion criteria

Exclusion criteria: History of dialysis or renal failure, Use of N-acetylcysteine or sodium bicarbonate, Received contrast agent within the past 7 days, Use of study drugs within the past month

Design outcomes

Primary

MeasureTime frame
Contrast nephropathy. Timepoint: Before and 72 hours after the intervention. Method of measurement: With creatinine measurement.

Secondary

MeasureTime frame
Any adverse events (including: headache, dizziness, hypotension, nausea and vomiting, constipation, stomach ulcers, skin reactions). Timepoint: 72 hours after the intervention. Method of measurement: With history taking and clinical examination.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactPouyan Lotfi

Hamedan University of Medical Sciences

pouyanbio@gmail.com+98 81 3838 0572

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 7, 2026