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Effect of N-acetylcysteine versus Bromhexine on clinical symptoms in patients with acute exacerbation of chronic obstructive pulmonary disease

Effect of N-acetylcysteine versus Bromhexine on clinical symptoms in patients with acute exacerbation of chronic obstructive pulmonary disease: a double-blind randomized clinical trial

Status
Active, not recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20120215009014N580
Enrollment
60
Registered
2025-10-07
Start date
2025-11-06
Completion date
Unknown
Last updated
2025-10-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Chronic obstructive pulmonary disease. Chronic obstructive pulmonary disease with acute lower respiratory infection

Interventions

Intervention 1: Intervention group 1: Routine treatment of patients with chronic obstructive pulmonary disease plus effervescent tablets of N-acetylcysteine dissolved in a cup of water at a dose of 60

Sponsors

Hamedan University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
50 Years to 80 Years

Inclusion criteria

Inclusion criteria: Age 50 to 80 years, Chronic obstructive pulmonary disease,

Exclusion criteria

Exclusion criteria: Lung cancer, Heart failure, Asthma

Design outcomes

Primary

MeasureTime frame
Arterial oxygen saturation. Timepoint: Before intervention and 48 hours later, and at discharge. Method of measurement: using a monitor.;Dyspnea. Timepoint: Before intervention and 48 hours later, and at discharge. Method of measurement: using the Modified Medical Research Council Dyspnea Scale.;Cough and sputum. Timepoint: Before intervention and 48 hours later, and at discharge. Method of measurement: Using history and physical examination.;Days of hospitalization. Timepoint: At discharge. Method of measurement: Using patient medical records.

Secondary

MeasureTime frame
Any adverse event (drowsiness, hypersensitivity). Timepoint: 48 hours later and at discharge. Method of measurement: Using history and physical examination.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactNazanin Ghasemi Majd

Hamedan University of Medical Sciences

nazimajdd3@gmail.com+98 81 3838 0572

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026