Effect of zinc supplementation versus placebo on chemical and molecular biomarkers of ferroptosis in acute stroke patients

Effect of zinc supplementation versus placebo on chemical and molecular biomarkers of ferroptosis in acute stroke patients: a double-blind randomized clinical trial

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20120215009014N579

Enrollment

Registered

2025-10-07

Start date

2025-10-23

Completion date

Unknown

Last updated

2025-10-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Acute stroke. Cerebellar stroke syndrome

Interventions

Intervention 1: Intervention group: Routine treatment of patients with acute stroke plus one 30 mg zinc supplement tablet (manufactured by Midnature Pharmaceutical Company, USA) daily for three consec

Eligibility

Sex/Gender

All

Age

18 Years to 80 Years

Inclusion criteria

Inclusion criteria: Age 18 to 80 years, Acute stroke,

Exclusion criteria

Exclusion criteria: Use of immunosuppressive drugs, Swallowing disorder, Diabetes, Renal failure, History of open abdominal surgery

Design outcomes

Primary

Measure	Time frame
Serum lipid peroxidation levels. Timepoint: Before intervention and three days later. Method of measurement: By blood sampling.;Total blood antioxidant capacity. Timepoint: Before intervention and three days later. Method of measurement: by blood sampling.;Serum glutathione peroxidase and superoxide dismutase enzyme activities. Timepoint: Before intervention and three days later. Method of measurement: By blood sampling.;Serum iron and ferritin levels. Timepoint: Before intervention and three days later. Method of measurement: By blood sampling.	—

Measure

Time frame

Serum lipid peroxidation levels. Timepoint: Before intervention and three days later. Method of measurement: By blood sampling.;Total blood antioxidant capacity. Timepoint: Before intervention and three days later. Method of measurement: by blood sampling.;Serum glutathione peroxidase and superoxide dismutase enzyme activities. Timepoint: Before intervention and three days later. Method of measurement: By blood sampling.;Serum iron and ferritin levels. Timepoint: Before intervention and three days later. Method of measurement: By blood sampling.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactMobina Torabi

Hamedan University of Medical Sciences

torabi_mobina@yahoo.com+98 81 3838 0572

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026