Effect of intracoronary adenosine with epinephrine on myocardial perfusion in patients with ST elevation myocardial infarction who undergoing primary percutaneous coronary intervention with slow \ no re-flow phenomena

Effect of intracoronary adenosine with epinephrine on myocardial perfusion in patients with ST elevation myocardial infarction who undergoing primary percutaneous coronary intervention with slow \ no re-flow phenomena: a randomized clinical trial

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20120215009014N566

Enrollment

Registered

2025-07-28

Start date

2025-08-11

Completion date

Unknown

Last updated

2025-08-19

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Myocardial infarction. ST elevation (STEMI) myocardial infarction of unspecified site

Interventions

Intervention 1: Intervention group: Intracoronary infusion of epinephrine 100 to 600 micrograms in 10 mL of normal saline at a dose of 1 mL every two minutes. Intervention 2: Control group: Intracoron

Eligibility

Sex/Gender

All

Age

18 Years to 90 Years

Inclusion criteria

Inclusion criteria: Age 18 to 90 years Acute myocardial infarction with ST segment elevation Indication for primary angioplasty Slow/no-flow phenomenon

Exclusion criteria

Exclusion criteria: Valvular or congenital heart disease Contraindications to aspirin History of open-heart surgery History of stent thrombosis Use of fibrinolytics

Design outcomes

Primary

Measure	Time frame
Myocardial blood flow. Timepoint: immediately after drug infusion. Method of measurement: Using angiography.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr. Mahsa Tahaie

Hamedan University of Medical Sciences

sm.tahaie@gmail.com+98 81 3838 0572

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026