Effect of combined exercise (resistance exercise and high intensity interval training) versus control group on serum sirtuin 1 and 4 levels in men with non-alcoholic fatty liver disease

Effect of combined exercise (resistance exercise and high intensity interval training) versus control group on serum sirtuin 1 and 4 levels in men with non-alcoholic fatty liver disease: a randomized clinical trial

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT20120215009014N563

Enrollment

Registered

2025-07-15

Start date

2025-08-01

Completion date

Unknown

Last updated

2025-07-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Fatty liver. Fatty (change of) liver, not elsewhere classified

Interventions

Intervention 1: Intervention group: Training and routine recommendations plus combined resistance exercise and high-intensity interval training (HIIT) for 45 to 60 minutes, 3 days a week, for 12 weeks

Eligibility

Sex/Gender

Male

Age

18 Years to 50 Years

Inclusion criteria

Inclusion criteria: Age 18 to 50 years Non-alcoholic fatty liver grade 1 and 2

Exclusion criteria

Exclusion criteria: Heart or respiratory disease Thyroid disorder Diabetes Muscle and joint disorders Smoking and alcohol use

Design outcomes

Primary

Measure	Time frame
Sirtuin 1 levels. Timepoint: Before intervention and 12 weeks later. Method of measurement: Using blood sampling.;Sirtuin 4 levels. Timepoint: Before intervention and 12 weeks later. Method of measurement: Using blood sampling.;Serum liver enzymes (ALT-AST). Timepoint: Before intervention and 12 weeks later. Method of measurement: Using blood sampling.;Serum lipid profile (LDL-HDL-CHOL-TG). Timepoint: Before intervention and 12 weeks later. Method of measurement: Using blood sampling.;Serum fasting blood glucose levels. Timepoint: Before intervention and 12 weeks later. Method of measurement: Using blood sampling.;Body mass index. Timepoint: Before intervention and 12 weeks later. Method of measurement: Using physical examination.;Waist-hip ratio. Timepoint: Before intervention and 12 weeks later. Method of measurement: Using physical examination.	—

Measure

Time frame

Sirtuin 1 levels. Timepoint: Before intervention and 12 weeks later. Method of measurement: Using blood sampling.;Sirtuin 4 levels. Timepoint: Before intervention and 12 weeks later. Method of measurement: Using blood sampling.;Serum liver enzymes (ALT-AST). Timepoint: Before intervention and 12 weeks later. Method of measurement: Using blood sampling.;Serum lipid profile (LDL-HDL-CHOL-TG). Timepoint: Before intervention and 12 weeks later. Method of measurement: Using blood sampling.;Serum fasting blood glucose levels. Timepoint: Before intervention and 12 weeks later. Method of measurement: Using blood sampling.;Body mass index. Timepoint: Before intervention and 12 weeks later. Method of measurement: Using physical examination.;Waist-hip ratio. Timepoint: Before intervention and 12 weeks later. Method of measurement: Using physical examination.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactRazieh Ghorbani Saber

Hamedan University of Medical Sciences

razih.saber@gmail.com+98 81 3838 0572

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026