Primary angioplasty. Angioplasty status
Conditions
Interventions
Intervention 1: Intervention group: Routine treatment measures plus melatonin injection of 20 mg as a single dose immediately before angioplasty, then melatonin injection of 10 mg for 3 days. Interven
Sponsors
Iran University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: Age 18 to 70 years Primary angioplasty candidate Symptoms of cardiac ischemia persist for at least 30 minutes Less than 12 hours have passed since the onset of myocardial infarction symptoms ST segment elevation in electrocardiogram
Exclusion criteria
Exclusion criteria: Consumption of antioxidant compounds in the last month Taking other drugs with nephrotoxic effects Candidate patients for thrombolytic therapy Cardiogenic shock Advanced liver failure Heart failure Autoimmune diseases
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Plasma creatinine level. Timepoint: Before intervention and at 24, 48 and 72 hours later. Method of measurement: By blood sampling.;BUN plasma level. Timepoint: Before intervention and at 24, 48 and 72 hours later. Method of measurement: By blood sampling.;Plasma level of eGFR. Timepoint: Before intervention and at 24, 48 and 72 hours later. Method of measurement: By blood sampling. | — |
Secondary
| Measure | Time frame |
|---|---|
| Plasma level of lipid peroxidation, superoxide dismutase and glutathione peroxidase. Timepoint: Before the intervention and 72 hours later. Method of measurement: By blood sampling.;Plasma level of CRP. Timepoint: Before the intervention and 72 hours later. Method of measurement: By blood sampling. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactDr. Azadeh Eshraghi
Iran University of Medical Sciences
Outcome results
None listed