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Effect of propofol compared to the combination of propofol and etomidate on hemodynamic responses to tracheal intubation in elective surgeries

Effect of propofol compared to the combination of propofol and etomidate on hemodynamic responses to tracheal intubation in elective surgeries: a double-blind randomized clinical trial

Status
Recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20120215009014N536
Enrollment
88
Registered
2024-11-09
Start date
2024-12-01
Completion date
Unknown
Last updated
2025-01-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Systolic and diastolic blood pressure. Abnormal blood-pressure reading, without diagnosis

Interventions

Intervention 1: Intervention group: Propofol injection 1.5 mg/kg along with etomidate injection 0.15 mg/kg before anesthesia and tracheal intubation. Intervention 2: Control group: Injection of propof

Sponsors

Hamedan University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 60 Years

Inclusion criteria

Inclusion criteria: Age 18 to 60 years Elective surgery indication

Exclusion criteria

Exclusion criteria: Stability of hemodynamic status Pregnancy Addiction to alcohol and psychotropic drugs Body mass index above 30

Design outcomes

Primary

MeasureTime frame
Heart rate immediately. Timepoint: After anesthesia, before tracheal intubation and then one, five and ten minutes after tracheal intubation. Method of measurement: Using a monitor device.;Systolic and diastolic blood pressure. Timepoint: After anesthesia, before tracheal intubation and then one, five and ten minutes after tracheal intubation. Method of measurement: Using a monitor device.;Mean arterial blood pressure. Timepoint: After anesthesia, before tracheal intubation and then one, five and ten minutes after tracheal intubation. Method of measurement: Using a monitor device.

Secondary

MeasureTime frame
Side effects (such as hiccups, swelling, redness at the injection site, or allergic symptoms). Timepoint: 30 minutes after the intervention. Method of measurement: With clinical examinations.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactMarzieh Mahdi

Hamedan University of Medical Sciences

mbahare41@gmail.com+98 81 3838 0572

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026