A comparison of the analgesic effect of ketorolac, morphine and Apotel in head trauma patients

A comparison of the analgesic effect of ketorolac, morphine and Apotel in head trauma patients: a triple-blind randomized clinical trial

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20120215009014N531

Enrollment

105

Registered

2024-10-05

Start date

2024-10-11

Completion date

Unknown

Last updated

2025-01-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Post-traumatic headache. Post-traumatic headache

Interventions

Intervention 1: Intervention group 1: Apotel infusion at a single dose of 15 mg/kg in 100 ml of normal saline over 15 minutes. Intervention 2: Intervention group 2: Ketorolac infusion at a single dose

Eligibility

Sex/Gender

All

Age

18 Years to 55 Years

Inclusion criteria

Inclusion criteria: Age 18 to 55 years Head trauma Headache intensity between 4 and 10 based on the Visual Analog Scale (VAS)

Exclusion criteria

Exclusion criteria: Impaired level of consciousness Bleeding and pathological lesion in brain CT scan Kidney, liver or heart and lung disease Pregnancy

Design outcomes

Primary

Measure	Time frame
Headache intensity. Timepoint: Before the intervention and 15 and 30 minutes after the intervention. Method of measurement: With visual analog scale (VAS).	—

Secondary

Measure	Time frame
Possible side effects (itching, dizziness, nausea and vomiting). Timepoint: 15 and 30 minutes after the intervention. Method of measurement: By taking history and clinical examination.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactMohammad Shakoori

Hamedan University of Medical Sciences

mohammad097845@gmail.com+98 81 3838 0572

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026