Effect of the interval between double trigger injection and oocyte retrieval on oocyte maturation and clinical pregnancy in patients with poor response to ovulation stimulation in assisted reproductive techniques

Effect of the interval between double trigger injection and oocyte retrieval on oocyte maturation and clinical pregnancy in patients with poor response to ovulation stimulation in assisted reproductive techniques: a single blind randomized clinical trial

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20120215009014N512

Enrollment

238

Registered

2024-05-19

Start date

2024-06-04

Completion date

Unknown

Last updated

2024-05-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Female infertility. Female infertility

Interventions

Intervention 1: Intervention group: Injection of double trigger including 10,000 IU BHCG and decapeptil 0.1 mg (2 ampoules), then follicle aspiration and egg retrieval guided by vaginal ultrasound 34

Eligibility

Sex/Gender

Female

Age

35 Years to 42 Years

Inclusion criteria

Inclusion criteria: Age 35 to 42 years Regular spontaneous menstrual cycle (24 to 35 days) Poor response to ovulation stimulation

Exclusion criteria

Exclusion criteria: Polycystic ovary syndrome Stage 3 or 4 endometriosis History of ovarian surgery

Design outcomes

Primary

Measure	Time frame
The ratio of oocytes obtained on the day of ovulation to the number of follicles larger and equal to 14 mm. Timepoint: ]n the intervention group 34 hours and in the control group 36 hours after trigger injection. Method of measurement: By microscope.	—

Secondary

Measure	Time frame
Counting the number of oocytes. Timepoint: On the day of ovulation. Method of measurement: By microscope.;Counting the number of 2PN. Timepoint: 24 hours after fertilization. Method of measurement: By microscope.;Counting the number of cleavage embryos. Timepoint: 3 days after fertilization. Method of measurement: By microscope.;Counting the number of blast embryos. Timepoint: 5 days after fertilization. Method of measurement: By microscope.;Counting the number of mII oocytes after ovulation. Timepoint: 3 days after fertilization. Method of measurement: By microscope.;Examining the cleavage stage. Timepoint: 3 days after fertilization. Method of measurement: By microscope.;Biochemical pregnancy. Timepoint: 2 weeks after embryo transfer. Method of measurement: By laboratory method with BHCG measurement.;Clinical pregnancy. Timepoint: 4 to 5 weeks after conception 4 to 5 weeks after conception. Method of measurement: By vaginal ultrasound.	—

Measure

Time frame

Counting the number of oocytes. Timepoint: On the day of ovulation. Method of measurement: By microscope.;Counting the number of 2PN. Timepoint: 24 hours after fertilization. Method of measurement: By microscope.;Counting the number of cleavage embryos. Timepoint: 3 days after fertilization. Method of measurement: By microscope.;Counting the number of blast embryos. Timepoint: 5 days after fertilization. Method of measurement: By microscope.;Counting the number of mII oocytes after ovulation. Timepoint: 3 days after fertilization. Method of measurement: By microscope.;Examining the cleavage stage. Timepoint: 3 days after fertilization. Method of measurement: By microscope.;Biochemical pregnancy. Timepoint: 2 weeks after embryo transfer. Method of measurement: By laboratory method with BHCG measurement.;Clinical pregnancy. Timepoint: 4 to 5 weeks after conception 4 to 5 weeks after conception. Method of measurement: By vaginal ultrasound.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr. Parvin Sadat Eslam Nik

Tehran University of Medical Sciences

p.eslamnik284@gmail.com+98 21 8163 3619

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026