Effect of metformin cream 30% versus azelaic acid cream 20% on the treatment of melasma

Effect of metformin cream 30% versus azelaic acid cream 20% on the treatment of melasma: a double-blind randomized clinical trial

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20120215009014N505

Enrollment

Registered

2024-03-18

Start date

2024-04-08

Completion date

Unknown

Last updated

2024-05-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Melasma. Chloasma

Interventions

Intervention 1: Intervention group: Metformin topical cream 30% is applied twice a day every 12 hours for 3 months on skin lesions. Intervention 2: Control group: Azelaic acid topical cream 20% is app

Eligibility

Sex/Gender

All

Age

18 Years to 70 Years

Inclusion criteria

Inclusion criteria: Age 18 to 70 years Melasma

Exclusion criteria

Exclusion criteria: Pregnancy or breastfeeding Taking systemic corticosteroids or oral contraceptive pills in the last 3 months Hypothyroidism or polycystic ovary

Design outcomes

Primary

Measure	Time frame
Clinical signs and symptoms of melasma. Timepoint: ??At time intervals of zero, one, two and three months after the intervention. Method of measurement: Using Melasma Area Severity Index (MAS).	—

Secondary

Measure	Time frame
Local side effects such as erythema, burning, peeling. Timepoint: One, two and three months after the intervention. Method of measurement: By taking history and clinical examination.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr Efat Nabie Navid

Hamedan University of Medical Sciences

nabie.navid1075@gmail.com+98 81 3838 0572

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026