Painful diabetic neuropathy. Diabetes mellitus due to underlying condition with diabetic neuropathy, unspecified
Conditions
Interventions
Intervention 1: Intervention group: Pregabalin 75 mg tablet at night plus 3% silymarin topical gel twice a day for 2 months. Intervention 2: Control group: Pregabalin 75 mg tablet at night plus placeb
Sponsors
Hamedan University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: Age of 18 to 65 years Diabetes mellitus type 1 or 2 Painful diabetic neuropathy
Exclusion criteria
Exclusion criteria: Pregnancy or breastfeeding Drug abuse Nondiabetic neuropathy Diabetic ulcer Liver or kidney disease
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Pain score. Timepoint: Before intervention and one and two months later. Method of measurement: Using visual analog scale (VAS).;Quality of life score. Timepoint: Before the intervention and one and two months later. Method of measurement: Using the World Health Organization Quality of Life Questionnaire. | — |
Secondary
| Measure | Time frame |
|---|---|
| Local complication (redness, itching). Timepoint: One and two months later the intervention. Method of measurement: By taking history and clinical examination. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactMohammad Reza Khodarahmi Ghahnavieh
Hamedan University of Medical Sciences
Outcome results
None listed