Analgesic effect of topical gel Silymarin versus placebo in patients with knee osteoarthritis

Analgesic effect of topical gel Silymarin versus placebo in patients with knee osteoarthritis: a double-blind randomized clinical trial

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20120215009014N498

Enrollment

Registered

2024-02-21

Start date

2024-04-06

Completion date

Unknown

Last updated

2024-03-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Condition 1: . Condition 2: Osteoarthritis of knee. Osteoarthritis of knee

Interventions

Intervention 1: Intervention group: Topical gel Silymarin 3% three times daily plus topical gel Piroxicam twice daily for 2 weeks. Intervention 2: Control group: Topical gel placebo three times daily

Eligibility

Sex/Gender

All

Age

18 Years to 70 Years

Inclusion criteria

Inclusion criteria: Age of 18 to 70 years Mild to moderate knee osteoarthritis

Exclusion criteria

Exclusion criteria: Inflammation of the knee artery Rheumatoid arthritis History of knee surgery

Design outcomes

Primary

Measure	Time frame
Pain score. Timepoint: Before the intervention and 2 weeks later. Method of measurement: Using Visual Analog Scale (VAS).	—

Secondary

Measure	Time frame
Probable side effects (reddish, pruritus). Timepoint: 2 weeks after the intervention. Method of measurement: By history taking and physical examination.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactHamid Reza Heydari

Hamedan University of Medical Sciences

Rezaheydari690@yahoo.com+98 81 3838 0572

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026