Effect of intravenous ketorolac and magnesium sulfate versus intravenous ketorolac and placebo on pain reduction in Colles' fracture

Effect of intravenous ketorolac and magnesium sulfate versus intravenous ketorolac and placebo on pain reduction in Colles' fracture: a triple-blind randomized clinical trial

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20120215009014N495

Enrollment

Registered

2024-02-02

Start date

2024-02-20

Completion date

Unknown

Last updated

2024-03-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Colles' fracture. Colles' fracture

Interventions

Intervention 1: Intervention group: Intravenous ketorolac 30 mg plus 50% magnesium sulfate infusion in 100 ml normal saline over 20 minutes. Intervention 2: Control group: Intravenous ketorolac 30 mg

Eligibility

Sex/Gender

All

Age

18 Years to 80 Years

Inclusion criteria

Inclusion criteria: Age of 18 to 80 years Colles' fracture

Exclusion criteria

Exclusion criteria: Unstable vital signs Neurovascular injuries Open fracture Drug addiction Cardiac arrhythmia Kidney or liver failure

Design outcomes

Primary

Measure	Time frame
Pain intensity. Timepoint: Before the intervention and in 20, 40 and 60 minutes after the intervention. Method of measurement: By Visual Analog Scale (VAS).	—

Secondary

Measure	Time frame
Heart rate. Timepoint: Before the intervention and in 20, 40 and 60 minutes after the intervention. Method of measurement: With the monitor device.;Blood pressure. Timepoint: Before the intervention and in 20, 40 and 60 minutes after the intervention. Method of measurement: With the monitor device.;Breathing rate. Timepoint: Before the intervention and in 20, 40 and 60 minutes after the intervention. Method of measurement: With the monitor device.;Oxygen saturation percentage. Timepoint: Before the intervention and in 20, 40 and 60 minutes after the intervention. Method of measurement: By pulse oximetry method.	—

Measure

Time frame

Heart rate. Timepoint: Before the intervention and in 20, 40 and 60 minutes after the intervention. Method of measurement: With the monitor device.;Blood pressure. Timepoint: Before the intervention and in 20, 40 and 60 minutes after the intervention. Method of measurement: With the monitor device.;Breathing rate. Timepoint: Before the intervention and in 20, 40 and 60 minutes after the intervention. Method of measurement: With the monitor device.;Oxygen saturation percentage. Timepoint: Before the intervention and in 20, 40 and 60 minutes after the intervention. Method of measurement: By pulse oximetry method.

—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr Hamed Motevali Abargooei

Hamedan University of Medical Sciences

g6pd1394@gmail.com+98 81 3838 0572

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026