Effect of memantine versus placebo on pain in patients undergoing knee joint surgery

Effect of memantine versus placebo on pain in patients undergoing knee joint surgery: a double-blind randomized clinical trial

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20120215009014N491

Enrollment

Registered

2023-12-02

Start date

2023-12-06

Completion date

Unknown

Last updated

2024-01-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

knee joint disorders. Other specified joint disorders, knee

Interventions

Intervention 1: Intervention group: Routine treatment plus memantine tablets 20 mg daily three days before surgery and then 10 mg daily after surgery for 2 weeks. Intervention 2: Control group: Routin

Eligibility

Sex/Gender

All

Age

18 Years to 70 Years

Inclusion criteria

Inclusion criteria: Age 18 to 70 years Candidate for knee joint surgery Physical health class 1 or 2

Exclusion criteria

Exclusion criteria: Chronic heart disease Psychiatric diseases Alzheimer's disease Drug or alcohol addiction

Design outcomes

Primary

Measure	Time frame
Pain score. Timepoint: On the first, second, third, fourth, fifth and fourteenth days after surgery. Method of measurement: Using Visual Analog Scale (VAS).;Pain quality. Timepoint: On the first, second, third, fourth, fifth and fourteenth days after surgery. Method of measurement: Using the McGill questionnaire.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr. Azadeh Eshraghi

Iran University of Medical Sciences

aepharm@gmail.com+98 21 8670 2503

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026