Effect of topical solution hydrogen peroxide 40% versus cryotherapy on the treatment of seborrheic keratosis lesions

Effect of topical solution hydrogen peroxide 40% versus cryotherapy on the treatment of seborrheic keratosis lesions: a single-blind randomized clinical trial

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20120215009014N489

Enrollment

Registered

2023-11-09

Start date

2023-11-22

Completion date

Unknown

Last updated

2023-11-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Seborrheic keratosis. Seborrheic keratosis

Interventions

Intervention 1: Intervention group: In the hydrogen peroxide treatment method, a 40% hydrogen peroxide solution is placed on the seborrheic keratosis lesions with a cotton swab for 20 seconds and repe

Eligibility

Sex/Gender

All

Age

18 Years to 70 Years

Inclusion criteria

Inclusion criteria: Age 18 to 70 years Bilateral facial seborrheic keratosis

Exclusion criteria

Exclusion criteria: Pregnancy or breastfeeding History of using anti-pigmentation drugs in the last 3 months Presence of wound, infection or active skin disease at the treatment site Lesions on the eyelids or around the eyes

Design outcomes

Primary

Measure	Time frame
Improvement rate of keratosis seborrheic lesions. Timepoint: In 2, 4, and 6 weeks after treatment. Method of measurement: By clinical examination.	—

Secondary

Measure	Time frame
Pain and burning. Timepoint: 20 minutes after treatment. Method of measurement: By taking history.;Erythema. Timepoint: 20 minutes after treatment. Method of measurement: With clinical examination.;Edema. Timepoint: 20 minutes after treatment. Method of measurement: With clinical examination.;Hypopigmentation. Timepoint: 20 minutes after treatment. Method of measurement: With clinical examination.;Hyperpigmentation. Timepoint: 20 minutes after treatment. Method of measurement: With clinical examination.	—

Measure

Time frame

Pain and burning. Timepoint: 20 minutes after treatment. Method of measurement: By taking history.;Erythema. Timepoint: 20 minutes after treatment. Method of measurement: With clinical examination.;Edema. Timepoint: 20 minutes after treatment. Method of measurement: With clinical examination.;Hypopigmentation. Timepoint: 20 minutes after treatment. Method of measurement: With clinical examination.;Hyperpigmentation. Timepoint: 20 minutes after treatment. Method of measurement: With clinical examination.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr Forough Bouryabaf

Hamedan University of Medical Sciences

foroughbouryabaf@gmail.com+98 81 3838 0572

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026