Effect of oral melatonin in controlling pruritus in patients with atopic dermatitis

Evaluation of the effect of oral melatonin versus placebo in controlling pruritus in patients with atopic dermatitis: a double-blind randomized clinical trial

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20120215009014N483

Enrollment

Registered

2023-09-29

Start date

2023-10-12

Completion date

Unknown

Last updated

2023-10-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Atopic dermatitis. Atopic dermatitis

Interventions

Intervention 1: Intervention group: Routine treatment includes combined urea 10% and Eucerin 90% ointment and fluocinolone 30% and Eucerin 70% ointment daily plus oral 3 mg melatonin supplement daily

Eligibility

Sex/Gender

All

Age

12 Years to 65 Years

Inclusion criteria

Inclusion criteria: Age 12 to 65 years Atopic dermatitis

Exclusion criteria

Exclusion criteria: Pregnancy or breastfeeding Liver, kidney, nervous or immune system disease Use of warfarin and fluvoxamine

Design outcomes

Primary

Measure	Time frame
The intensity of itching. Timepoint: Before the intervention and then 2, 4 and 6 weeks after the intervention. Method of measurement: Using visual analog scale (VAS).;Severity of atopic dermatitis. Timepoint: Before the intervention and then 2, 4 and 6 weeks after the intervention. Method of measurement: Using the Scoring Atopic Dermatitis tool (SCORAD).	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr. Ayda Nouri Danesh

Hamedan University of Medical Sciences

aydanouridanesh@gmail.com+98 81 3838 0572

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026