Comparison of the efficacy of hypertonic saline 5% with mannitol 20% on cerebral edema in ischemic and hemorrhagic stroke patients

Comparison of the efficacy of hypertonic saline 5% with mannitol 20% on cerebral edema in ischemic and hemorrhagic stroke patients: a randomized clinical trial

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20120215009014N480

Enrollment

100

Registered

2023-08-23

Start date

2023-09-06

Completion date

Unknown

Last updated

2023-10-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cerebellar stroke. Cerebellar stroke syndrome

Interventions

Intervention 1: Intervention group: Mannitol 20% first with a dose of 1.5 gr/kg, then 100 ml every 4 hours within 15 to 20 minutes and repeating it until the patient regains consciousness. Interventio

Eligibility

Sex/Gender

All

Age

18 Years to 80 Years

Inclusion criteria

Inclusion criteria: Age 18 to 80 years Stroke GCS score between 3 and 8 Systolic blood pressure greater than 90 mmHg Having at least one pupillary reaction

Exclusion criteria

Exclusion criteria: Anuria or creatinine higher than 2.5 Convulsions Hypoxia

Design outcomes

Primary

Measure	Time frame
Cerebral edema. Timepoint: Before the intervention and after consciousness. Method of measurement: By using MRI.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactAliakbar Sooleymanloo

Hamedan University of Medical Sciences

aliakbarsoleymanlo@gmail.com+98 81 3838 0572

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026