Comparison of the effect of induction with midazolam, propofol and etomidate on hemodynamic changes in patients with hypertension and ischemic heart disease undergoing open heart surgery

Comparison of the effect of induction with midazolam, propofol and etomidate on hemodynamic changes in patients with hypertension and ischemic heart disease undergoing open heart surgery: a double-blind randomized clinical trial

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20120215009014N458

Enrollment

Registered

2023-01-17

Start date

2023-02-09

Completion date

Unknown

Last updated

2023-02-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Condition 1: Ischemic heart disease. Condition 2: Hypertension. Chronic ischemic heart disease Essential (primary) hypertension

Interventions

Intervention 1: Intervention group 1: Intravenous infusion of midazolam 0.15 mg/kg as single dose. Intervention 2: Intervention group 2: Intravenous infusion of propofol 1.5 mg/kg as single dose. Inte

Eligibility

Sex/Gender

All

Age

40 Years to 70 Years

Inclusion criteria

Inclusion criteria: Age 40 to 70 years Having high blood pressure Ischemic heart disease Candidate for open heart surgery

Exclusion criteria

Exclusion criteria: Heart rate less than 25% Needs emergency surgery

Design outcomes

Primary

Measure	Time frame
Systolic blood pressure. Timepoint: Before induction of anesthesia and 1 minute after it, as well as during intubation and 1 and 5 minutes after it. Method of measurement: With a monitor device.;Diastolic blood pressure. Timepoint: Before induction of anesthesia and 1 minute after it, as well as during intubation and 1 and 5 minutes after it. Method of measurement: With a monitor device.;Heart rate. Timepoint: Before induction of anesthesia and 1 minute after it, as well as during intubation and 1 and 5 minutes after it. Method of measurement: With a monitor device.	—

Measure

Time frame

Systolic blood pressure. Timepoint: Before induction of anesthesia and 1 minute after it, as well as during intubation and 1 and 5 minutes after it. Method of measurement: With a monitor device.;Diastolic blood pressure. Timepoint: Before induction of anesthesia and 1 minute after it, as well as during intubation and 1 and 5 minutes after it. Method of measurement: With a monitor device.;Heart rate. Timepoint: Before induction of anesthesia and 1 minute after it, as well as during intubation and 1 and 5 minutes after it. Method of measurement: With a monitor device.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactZahra Lotfi Mey Abadi

Hamedan University of Medical Sciences

zhrlf96@gmail.com+98 81 3838 0572

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026