Effect of Phytochemical and skin lightening of herbal formulation of Punica granatum and Crocus sativus versus Azelaic acid cream in patients with post inflammatory hyperpigmentation

Effect of Phytochemical and skin lightening of herbal formulation of Punica granatum and Crocus sativus versus Azelaic acid cream in patients with post inflammatory hyperpigmentation: a double-blind randomized clinical trial

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20120215009014N450

Enrollment

Registered

2022-12-19

Start date

2023-02-20

Completion date

Unknown

Last updated

2023-02-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Postinflammatory hyperpigmentation. Postinflammatory hyperpigmentation

Interventions

Intervention 1: Intervention group: Herbal cream containing pomegranate and saffron extract on the left side of the face twice a day for 12 weeks. Intervention 2: Control group: Cream Azelaic acid 20%

Eligibility

Sex/Gender

All

Age

18 Years to 60 Years

Inclusion criteria

Inclusion criteria: Age 18 to 60 years Post-inflammatory hyperpigmentation

Exclusion criteria

Exclusion criteria: Pregnancy or breastfeeding Having a skin disease Taking retinoid drugs in the last three months Taking contraceptive or anti-inflammatory or immunosuppressive drugs

Design outcomes

Primary

Measure	Time frame
Improvement of hyperpigmentation signs. Timepoint: Before treatment and 4, 8 and 12 weeks after treatment. Method of measurement: Using post acne hyperpigmentation index (PAHPI).	—

Secondary

Measure	Time frame
Side effects (including dryness, redness or peeling of the skin at the site of application of the cream). Timepoint: At weeks 4 and 12. Method of measurement: By taking a history.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactFatemeh Hamidbeigi

Hamedan University of Medical Sciences

fh.moghadam1999@gmail.com+98 81 3838 0572

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026