Skip to content

Evaluating the efficacy of mirtazapine versus sertraline on depression symptoms in patients undergoing hemodialysis

Evaluating the efficacy of mirtazapine versus sertraline on depression symptoms in patients undergoing hemodialysis: a double-blind randomized clinical trial

Status
Active, not recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20120215009014N445
Enrollment
54
Registered
2022-11-09
Start date
2022-11-22
Completion date
Unknown
Last updated
2022-11-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Depression. Other depressive episodes

Interventions

Intervention 1: Intervention group: Tablet mirtazapine 7.5 mg daily for one week and then 15 mg daily for 11 weeks. Intervention 2: Control group: Tablet sertraline 50 mg daily for one week and then 1

Sponsors

Hamedan University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 75 Years

Inclusion criteria

Inclusion criteria: Age of 18 to 5 years Undergoing hemodialysis for at least 6 months Being literate Suffering from depression

Exclusion criteria

Exclusion criteria: Pregnancy or breastfeeding Receiving anti-depressant and anti-anxiety medication in the last 3 months Liver failure Use of drugs or alcohol

Design outcomes

Primary

MeasureTime frame
Depression score. Timepoint: In weeks 4, 8, and 12 after the treatment. Method of measurement: Using the Beck Inventory Questionnaire.

Secondary

MeasureTime frame
Quality of life score. Timepoint: After week 12. Method of measurement: Using Global Quality of Life Scale.;Serum albumin level. Timepoint: After week 12. Method of measurement: By using laboratory test.;Percentage of weight gain. Timepoint: After week 12. Method of measurement: By using weights.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactShadieh Shariati

Hamedan University of Medical Sciences

shadi.shariatyy@gmail.com+98 81 3838 0572

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 5, 2026