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Effect of coenzyme Q10 versus placebo on the prevention of contrast medium-induced nephropathy in patients undergoing primary angioplasty

Effect of coenzyme Q10 versus placebo on the prevention of contrast medium-induced nephropathy in patients undergoing primary angioplasty: a double-blind randomized clinical trial

Status
Recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20120215009014N414
Enrollment
50
Registered
2021-12-29
Start date
2021-12-25
Completion date
Unknown
Last updated
2022-01-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Angioplasty. Angioplasty status

Interventions

Intervention 1: Intervention group: Routine treatment (angiotensin inhibitors, statin, anti-placket, beta-blockers) plus one capsule Q10 400 mg (manufactured by Dana Pharmaceutical Co.) single dose im

Sponsors

Hamedan University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 75 Years

Inclusion criteria

Inclusion criteria: Age 18 to 75 years; Symptoms of persistent myocardial ischemia for at least 30 minutes; Less than 12 hours after the onset of heart attack symptoms; Increased ST segment on electrocardiogram; Treated with primary angioplasty;

Exclusion criteria

Exclusion criteria: Consumption of any antioxidants in the past month; Indication of cardiac bypass surgery; History of myocardial infarction or angioplasty; Indication of thrombolytic therapy; Cardiogenic shock; History of heart failure; Advanced liver failure or autoimmune or inflammatory diseases

Design outcomes

Primary

MeasureTime frame
Nephropathy. Timepoint: Before the intervention and 24, 48, 72 hours after the intervention. Method of measurement: By measuring serum levels of BUN, creatinine and Estimated glomerular filtration rate (eGFR).

Secondary

MeasureTime frame
Serum level of CRP. Timepoint: Before the intervention and 24, 48, 72 hours. Method of measurement: After the intervention by laboratory test.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactAyesheh Rahmani

Hamedan University of Medical Sciences

ayshehr97@gmail.com+98 918 458 5937

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 10, 2026