Effect of sodium valproate versus acetaminophen on the treatment of acute phase of headache after mild head injury

Effect of sodium valproate versus acetaminophen on the treatment of acute phase of headache after mild head injury: a double-blind randomized clinical trial

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20120215009014N400

Enrollment

Registered

2021-06-24

Start date

2021-07-06

Completion date

Unknown

Last updated

2021-07-12

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Mild head injury. Superficial injury of head

Interventions

Intervention 1: Intervention group: Routine care after discharge plus tablet sodium valproate 200 mg (manufactured by Rha Co.) once every 12 hours for 3 weeks. Intervention 2: Control group: Routine c

Eligibility

Sex/Gender

All

Age

18 Years to 75 Years

Inclusion criteria

Inclusion criteria: Age of 18 to 75 years; Migraine headache after mild head injury;

Exclusion criteria

Exclusion criteria: History of headache under treatment; Hypertension; Diabetes; Cerebrovascular diseases Cardiovascular diseases

Design outcomes

Primary

Measure	Time frame
Severity of headache. Timepoint: Before the intervention and after first, second, and third week. Method of measurement: Using visual analog scale (VAS).	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactFaraneh Mirzaei

Hamedan University of Medical Sciences

www.farzanehmirazaie95@gmail.com+98 81 3838 0572

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026