Effect of 0.1% sodium hypochlorite mouthwash versus normal saline in early reducing intraoral viral load among patients with COVID-19

Effect of 0.1% sodium hypochlorite mouthwash versus normal saline in early reducing intraoral viral load among patients with COVID-19: a double-blind randomized clinical trial

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20120215009014N398

Enrollment

118

Registered

2021-06-20

Start date

2021-07-06

Completion date

Unknown

Last updated

2021-06-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

COVID-19. COVID-19

Interventions

Intervention 1: Intervention group: Gargling 0.1% sodium hypochlorite mouthwash 20 ml once for 30 seconds. Intervention 2: Control group: Gargling normal saline 20 ml once for 30 seconds.

Eligibility

Sex/Gender

All

Age

18 Years to 70 Years

Inclusion criteria

Inclusion criteria: Age of 18 to 70 years; Mild to moderate Covid-19 disease; Need for hospitalization;

Exclusion criteria

Exclusion criteria: Pregnancy or breastfeeding; Oral disease; Simultaneous use of other mouthwashes; Patients under mechanical ventilation; Patients with decreased level of consciousness;

Design outcomes

Primary

Measure	Time frame
Oral viral load. Timepoint: Before the intervention and 30 minutes after intervention. Method of measurement: Using oropharyngeal swab.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr Maryam Mehrpooya

Hamedan University of Medical Sciences

m_mehrpooya2003@yahoo.com+98 81 3838 0572

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026