Comparison of the effect of three medications on clinical symptoms of patients undergoing open heart surgery

Comparison of the effect of midazolam, etomidate and propofol on hemodynamic changes in patients undergoing coronary artery bypass graft surgery: a double -blind randomized clinical trial

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20120215009014N391

Enrollment

Registered

2021-04-23

Start date

2021-05-22

Completion date

Unknown

Last updated

2021-05-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Coronary artery bypass graft surgery. Atherosclerosis of coronary artery bypass graft(s), unspecified, with unspecified angina pectoris

Interventions

Intervention 1: Intervention group 1: Intravenous infusion of midazolam (manufactured by Oxir Pharmaceutical Co.) 0.15 mg/kg single dose before anesthesia. Intervention 2: Intervention group 2: Intra

Eligibility

Sex/Gender

All

Age

40 Years to 70 Years

Inclusion criteria

Inclusion criteria: Age of 40 to 70 years, Candidate for coronary artery bypass graft surgery,

Exclusion criteria

Exclusion criteria: Diabetes, Requires emergency coronary artery bypass graft surgery

Design outcomes

Primary

Measure	Time frame
Heart rate. Timepoint: One minute before induction of anesthesia and at 1, 2, 5 and 10 minutes after intubation. Method of measurement: Using monitoring machine.;Systolic blood pressure. Timepoint: One minute before induction of anesthesia and at 1, 2, 5 and 10 minutes after intubation. Method of measurement: Using monitoring machine.;Mean arterial blood pressure. Timepoint: One minute before induction of anesthesia and at 1, 2, 5 and 10 minutes after intubation. Method of measurement: Using monitoring machine.;Electrocardiographic changes. Timepoint: One minute before induction of anesthesia and at 1, 2, 5 and 10 minutes after intubation. Method of measurement: Using monitoring machine.;Diastolic blood pressure. Timepoint: One minute before induction of anesthesia and at 1, 2, 5 and 10 minutes after intubation. Method of measurement: Using monitoring machine.	—

Measure

Time frame

Heart rate. Timepoint: One minute before induction of anesthesia and at 1, 2, 5 and 10 minutes after intubation. Method of measurement: Using monitoring machine.;Systolic blood pressure. Timepoint: One minute before induction of anesthesia and at 1, 2, 5 and 10 minutes after intubation. Method of measurement: Using monitoring machine.;Mean arterial blood pressure. Timepoint: One minute before induction of anesthesia and at 1, 2, 5 and 10 minutes after intubation. Method of measurement: Using monitoring machine.;Electrocardiographic changes. Timepoint: One minute before induction of anesthesia and at 1, 2, 5 and 10 minutes after intubation. Method of measurement: Using monitoring machine.;Diastolic blood pressure. Timepoint: One minute before induction of anesthesia and at 1, 2, 5 and 10 minutes after intubation. Method of measurement: Using monitoring machine.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactParsa Afghanian

Hamedan University of Medical Sciences

parsaafn@yahoo.com+98 81 3838 0572

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026