Effect of Dexmedetomidine versus Transaxamic acid on intraoperative bleeding during functional endoscopic sinus surgery

Effect of Dexmedetomidine versus Transaxamic acid on intraoperative bleeding during functional endoscopic sinus surgery: a triple-blind randomized clinical trial

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20120215009014N390

Enrollment

Registered

2021-04-18

Start date

2021-04-21

Completion date

Unknown

Last updated

2021-05-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Chronic rhino sinusitis. Chronic sinusitis

Interventions

Intervention 1: Intervention group 1: Transaxamic acid injection (manufactured by Caspian Pharmaceutical Co.) 11 mgr/kg by intravenous infusion within 15 minutes. Intervention 2: Intervention group 2:

Eligibility

Sex/Gender

All

Age

18 Years to 61 Years

Inclusion criteria

Inclusion criteria: Age of 18 to 61 years, Chronic rhino sinusitis with or without polyposis, Candidate for functional endoscopic sinus surgery,

Exclusion criteria

Exclusion criteria: Coagulopathy disorders, Taking anticoagulant medication in the last 5 days, History of thromboembolism, Acute or chronic renal failure, Hepatic cirrhosis, Uncontrolled chronic diseases such as hypertension, diabetes, heart failure, Having cardiac stent, Pregnancy

Design outcomes

Primary

Measure	Time frame
Intraoperative bleeding volume. Timepoint: At 15, 30, 60 and 90 minutes after the start of surgery. Method of measurement: Using a calibrated suction chamber after reducing the volume of normal saline.	—

Secondary

Measure	Time frame
Hemodynamic changes. Timepoint: At 15, 30, 60 and 90 minutes after the start of surgery. Method of measurement: Using monitoring machine.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr Negar Ghaghi

Hamedan University of Medical Sciences

negarhaghi27@yahoo.com+98 81 3838 0572

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026