Effect of low dose intravenous ketamine versus placebo on the prevention of headache after spinal anesthesia in patients who are candidates for cesarean section

Effect of low dose intravenous ketamine versus placebo on the prevention of headache after spinal anesthesia in patients who are candidates for cesarean section: a double-blind randomized clinical trial

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20120215009014N387

Enrollment

Registered

2021-03-09

Start date

2021-04-04

Completion date

Unknown

Last updated

2021-04-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Headache. Tension-type headache, unspecified

Interventions

Intervention 1: Intervention group: intravenous injection of ketamine (manufactured by the Sterop Pharmaceutical Co., Belgium) 0.15 mg/kg immediately after spinal anesthesia. Intervention 2: Control g

Eligibility

Sex/Gender

Female

Age

16 Years to 45 Years

Inclusion criteria

Inclusion criteria: Age: 16 to 45 years old Candidates for elective cesarean section

Exclusion criteria

Exclusion criteria: History of heart, respiratory, renal, or neurologic diseases History of chronic headache or migraine History of allergy to anesthesia medications Preeclampsia

Design outcomes

Primary

Measure	Time frame
Headache. Timepoint: On the first to the third days after surgery. Method of measurement: Using Visual Analog Scale (VAS).	—

Secondary

Measure	Time frame
Vomiting. Timepoint: During surgery. Method of measurement: By clinical observation.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactTahereh Ataei-Rad

Hamedan University of Medical Sciences

tahere_ataei@yahoo.com+98 81 3838 0572

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026